Recently a group of experts from the oncology research community, academia, cancer cooperative groups, patient advocacy and industry identified ten trials as high priority colorectal clinical studies that address important research opportunities and merit support for rapid completion.  Combined, these ten large studies require more than 17,500 participants.

The Coalition’s Scientific Leadership Council in Gastrointestinal Cancer presented these trials as part of their recommendations for the future direction of colorectal cancer research at a forum in Washington DC in December 2005 and at a major GI cancer meeting in San Francisco in January 2006.

Following is a list of these ten priority colorectal cancer clinical trials.  The first listing is a screening trial for the detection of colon polyps and cancer in healthy participants.  The nine listings that follow are treatment trials for colorectal cancer patients.  Please click here to determine if you are eligible for these treatment trials.

Early-stage Colon Cancer (combined with surgery)

Protocol ID: ECOG-E5202
Protocol Title: Phase III Randomized Study of Oxaliplatin, Leucovorin Calcium, and  Fluorouracil With  Versus Without Bevacizumab in Patients With Resected Stage II Colon Cancer
View Locations Where this Study is Available
Read Summary of Trial
Screen Trials for Eligibility

Protocol ID: NCCTG-N0147
Protocol Title: A Randomized Phase III Trial of Oxaliplatin (OXAL) Plus 5-Fluorouracil (5-FU)/Leucovorin (CF) with or without Cetuximab (C225) After Curative Resection for Patients with Stage III Colon Cancer
View Locations Where this Study is Available
Read Summary of Trial
Screen Trials for Eligibility

Protocol ID: NSABP-C-08
Protocol Title: Phase III Randomized Study of Adjuvant Chemotherapy Comprising Fluorouracil, Leucovorin Calcium,  and Oxaliplatin With Versus Without Bevacizumab in Patients With Resected Stage II or III Adenocarcinoma of the Colon
View Locations Where this Study is Available
Read Summary of Trial
Screen Trials for Eligibility

Early-stage Rectal Cancer (combined with surgery)

Protocol ID: E5204
Protocol Title: Phase III Study of Postoperative Oxaliplatin, 5-Fluorouracil and Leucovorin vs Oxaliplatin, 5-Fluorouracil, Leucovorin and Bevacizumab for Patients w/ Stage II or III Rectal Cancer Receiving Pre-operative Chemoradiation
For more information on this trial, please call Kelly Glacken at 215-399-0424
View Locations Where this Study is Available
Read Summary of Trial
Screen Trials for Eligibility

Protocol ID: NSABP-R-04
Protocol Title: Randomized Study of Preoperative Chemoradiotherapy Comprising Radiation Therapy and Either Capecitabine or Fluorouracil With or Without Oxaliplatin in Patients With Resectable Rectal Cancer
View Locations Where this Study is Available
Read Summary of Trial
Screen Trials for Eligibility

Advanced Colorectal Cancer (Colorectal Cancer that has Spread to Other Organs)

Protocol ID: C80405
Protocol Title: A Phase III Trial of Irinotecan/5-FU/Leucovorin or Oxaliplatin/5-FU/Leucovorin with Bevacizumab, or Cetuximab (C225), or with the Combination of Bevacizumab and Cetuximab for Patients with Untreated Metastatic Adenocarcinoma of the Colon or Rectum
View Locations Where this Study is Available
Read Summary of Trial
Screen Trials for Eligibility

Protocol ID: NSABP-C-09
Protocol Title: Phase III Randomized Study of Adjuvant Therapy Comprising Oxaliplatin and Capecitabine With Versus Without Hepatic Arterial Infusion of Floxuridine in Patients Undergoing Surgical Resection and/or Ablation for Hepatic Metastases From Colorectal Cancer
View Locations Where this Study is Available
Read Summary of Trial
Screen Trials for Eligibility

Protocol ID: ECOG-E4203
Protocol Title: Phase II Study of Treatment Selection Based Upon Tumor Thymidylate Synthase Expression in Previously Untreated Patients With Metastatic Colorectal Cancer
View Locations Where this Study is Available
Read Summary of Trial
Screen Trials for Eligibility